Publications

A pan-African pathogen genomics data sharing platform to support disease outbreaks

May 22, 2023

In a recent post in The Conversation, SANBI Director Professor Alan Christoffels and Africa CDC Pathogen Genomics Programme Lead Dr Sofonias Tessema explain the need for a repository for pathogen data sharing between African countries: Infectious disease outbreaks in African countries are, unfortunately, all too common. Ebola in the Democratic Republic of the Congo or Uganda; Marburg […]

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University of the Western Cape (UWC) and the University of Stellenbosch make publish new discoveries in HIV-1 Drug resistance and gene isolation for Parkinsons Disease.

August 26, 2021

Dr. Ruben Cloete and his research group, together with researchers at the University of Stellenbosch, have recently published two papers. The first paper details their analysis work on drug resistance in HIV-1 integrase, and the second on identifying plausible candidate genes for Parkinson’s disease. A brief summary follows below. Drug resistance analysis in HIV-1 Integrase:

University of the Western Cape (UWC) and the University of Stellenbosch make publish new discoveries in HIV-1 Drug resistance and gene isolation for Parkinsons Disease. Read More »

Africa joins the race to trace COVID-19 with genomics

April 20, 2020

Congratulations to our very own Peter van Heusden, who’s article has been published in The Conversation. The article highlights the importance of virus sequencing and genomic epidemiology in assisting the public health response to COVID-19. https://theconversation.com/africa-joins-the-race-to-trace-covid-19-with-genomics-136427

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Whole-Genome Sequence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) obtained from a South African Coronavirus Disease 2019 (COVID-19) Patient

April 5, 2020

A complete genome sequence was obtained for a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) isolated from a South African patient with coronavirus disease 2019 (COVID-19), who had returned to South Africa after travelling to Italy. SANBI Contributing authors: Dr Ruben Cloete and Peter van Heusden on behalf of the SA-COVID-19 response team and in

Whole-Genome Sequence of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) obtained from a South African Coronavirus Disease 2019 (COVID-19) Patient Read More »

Ability To Develop Broadly Neutralizing HIV-1 Antibodies…

April 10, 2015

Ability To Develop Broadly Neutralizing HIV-1 Antibodies Is Not Restricted by the Germline Ig Gene Repertoire This work is part of our ongoing collaboration with CAPRISA and shows that there is no difference in the germline IGHV repertoires between individuals who do and do not develop broadly neutralizing antibodies. This is significant because it suggests that

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RAMICS: fast high-throughput sequence alignment

May 28, 2014

RAMICS is a method developed at SANBI that undertakes fast and highly accurate mapping/alignment of coding sequence reads in a biologically relevant manner. It identifies, and accounts for, PCR and sequencing induced errors resulting in an alignment that maintains the correct reading frame thereby enabling SNPs to be distinguished from noise. The challenge presented by

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